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Advances and perspectives in acne therapy

T Jansen¹, G Plewig

¹Department of Dermatology, Ludwig-Maximilians-University, Frauenlobstr. 9-11, Munich, D-80337, Germany.

European Journal of Medical Research

|August 28, 1997

Summary

Effective acne treatment targets abnormal keratinization and Propionibacterium acnes proliferation. Oral isotretinoin is the only therapy that alters acne

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Area of Science:

Dermatology
Medical Science

Background:

Acne vulgaris is a prevalent skin condition with significant cosmetic and psychological impacts.
While acne often resolves spontaneously, timely interventions can mitigate severity and prevent scarring.

Purpose of the Study:

To outline current, pathogenically-guided treatment strategies for acne vulgaris.
To discuss therapeutic options based on disease severity and specific acne types.

Main Methods:

Review of contemporary treatment modalities for acne.
Focus on combination therapies addressing keratinization and bacterial proliferation.
Consideration of sebum suppression and systemic isotretinoin for severe cases.

Main Results:

Combination therapy effectively controls acne in most patients by targeting key pathogenic factors.
Severe or resistant cases may require sebum-suppressing agents or oral isotretinoin.
Oral isotretinoin is uniquely capable of altering the disease's natural progression.

Conclusions:

Modern acne management employs targeted therapies based on understanding disease mechanisms.
A stepwise approach, from combination drugs to isotretinoin, offers effective disease control.
Early surgical intervention is recommended for acne inversa.

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