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Heart valve operation in acromegaly
G Ohtsuka1, S Aomi, H Koyanagi
1Department of Cardiovascular Surgery, Heart Institute of Japan, Tokyo Women's Medical College, Japan.
The Annals of Thoracic Surgery
|August 1, 1997
Summary
Valvular heart disease, though rare in acromegaly, can lead to serious complications. This study reports on five successful surgical interventions for acromegaly patients with valvular heart disease.
Area of Science:
- Cardiology
- Endocrinology
- Surgical Pathology
Background:
- Acromegaly, a condition of excess growth hormone, commonly causes congestive heart failure.
- Valvular heart disease is an infrequent but serious cardiac complication in acromegaly patients.
Purpose of the Study:
- To describe the clinical and pathological features of five surgical cases of valvular heart disease associated with acromegaly.
- To highlight the importance of surgical intervention in managing valvular heart disease in acromegalic patients.
Main Methods:
- Retrospective analysis of patient characteristics.
- Review of operative and histopathologic findings in five surgical cases.
Main Results:
- Five patients (4 male, 1 female; mean age 59 years) underwent valve replacement surgery.
- Common lesions included mitral regurgitation and aortic regurgitation, with causes like degeneration and annular dilatation.
- Histopathology revealed mucopolysaccharide deposits, myxomatous degeneration, myocardial fibrosis, and disarranged muscle fibers.
Conclusions:
- Successful surgical management of valvular heart disease in acromegaly is feasible.
- Early surgical intervention is recommended due to the risk of acromegalic cardiomyopathy.