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Related Experiment Videos

Quantitative 99mTc-pertechnetate thyroid scintigraphy in normal beagles

W H Adams1, G B Daniel, M G Petersen

  • 1Department of Small Animal Clinical Sciences, University of Tennessee, College of Veterinary Medicine, Knoxville 37901-1071, USA.

Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association
|July 1, 1997
PubMed
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This study validated canine thyroid/salivary (T/S) ratios in normal dogs, finding values around 1 initially but declining over time. Thyroid uptake of 99mTc-pertechnetate was also quantified, aiding in diagnosing canine thyroid conditions.

Area of Science:

  • Veterinary Nuclear Medicine
  • Canine Endocrinology
  • Diagnostic Imaging

Background:

  • Thyroid/salivary (T/S) ratios are used to assess thyroid function in dogs.
  • Published T/S ratios for normal dogs are approximately 1.
  • Accurate reference ranges are crucial for diagnosing thyroid disorders.

Purpose of the Study:

  • To validate published canine thyroid/salivary (T/S) ratios in normal dogs.
  • To determine the thyroid uptake of 99mTc-pertechnetate in healthy Beagles.
  • To establish reference ranges for T/S ratios and pertechnetate uptake over time.

Main Methods:

  • Evaluated 13 Beagle dogs over a 4-hour period.
  • Measured thyroid/salivary ratios of 99mTc-pertechnetate at various time points.

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  • Quantified percent uptake of injected dose in the thyroid gland.

    • Main Results:

    • Mean T/S ratios were approximately 1.2 at 20 minutes and 1 hour, declining to 0.6 at 4 hours.
    • Maximum thyroid uptake of 99mTc-pertechnetate averaged 0.55% +/- 0.15%.
    • Peak uptake occurred at a mean of 160 +/- 55 minutes post-injection.

    Conclusions:

    • The study provides validated T/S ratio data for normal dogs, showing a decline over time.
    • Established uptake parameters for 99mTc-pertechnetate in canine thyroid glands.
    • Data can aid in the evaluation of canine thyroid diseases, including hypothyroidism.