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Urticaria pigmentosa presenting with massive peripheral eosinophilia
R L Stern1, S M Manders, S H Buttress
1Department of Medicine, Cooper Hospital/University Medical Center, UMDNJ-Robert Wood Johnson Medical School, Camden 08103, USA.
Pediatric Dermatology
|July 1, 1997
Summary
Mastocytosis, a rare condition, can cause significant peripheral eosinophilia in infants. Early diagnosis and management involving antihistamines and avoiding mast cell degranulators are crucial for improvement.
Area of Science:
- Pediatric Dermatology
- Hematology
- Immunology
Background:
- Eosinophilia, elevated eosinophil counts, can indicate various underlying conditions in pediatric patients.
- Mastocytosis is a rare disorder characterized by the abnormal accumulation of mast cells.
Observation:
- A 5-month-old Hispanic boy presented with a diffuse skin eruption and marked peripheral eosinophilia.
- Diagnostic workup included skin biopsy, Giemsa stain, bone marrow examination, and cultures.
Findings:
- Skin biopsy confirmed mastocytosis.
- Other potential causes of eosinophilia were excluded.
- Patient's condition improved with antihistamine treatment and avoidance of mast cell degranulating agents.
Implications:
- Mastocytosis should be considered in the differential diagnosis of pediatric eosinophilia.
- This case highlights the importance of recognizing mastocytosis in infants presenting with eosinophilia and skin manifestations.
- Prompt diagnosis and appropriate management can lead to favorable clinical outcomes.