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Endogenous retroviruses and the evolution of resistance to retroviral infection
S Best1, P R Le Tissier, J P Stoye
1Wellcome Trust Centre for Human Genetics, Oxford, UK. sbest@well.ox.ac.uk
Trends in Microbiology
|August 1, 1997
Abstract:
The current AIDS epidemic has rekindled interest in the evolution of retroviruses and the development of resistance to infection. Retroviruses and their vertebrate hosts have coexisted for millions of years, during which time a variety of host defence mechanisms has evolved. One repeated strategy is to use endogenous retroviruses to combat infection by their exogenous relatives.