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Fetal pyelectasis in consecutive pregnancies: a possible genetic predisposition
S Degani1, Z Leibovitz, I Shapiro
1Department of Obstetrics and Gynecology, Bnai-Zion Medical Center, Haifa, Israel.
Summary
Mild fetal pyelectasis, a common finding during pregnancy ultrasound, frequently recurs in subsequent pregnancies. This suggests a potential genetic or environmental predisposition for developing fetal kidney dilation.
Area of Science:
- Perinatal Medicine
- Fetal Medicine
- Pediatric Nephrology
Background:
- Mild fetal pyelectasis is a common prenatal ultrasound finding.
- Understanding its recurrence is crucial for parental counseling and management.
- Previous data on recurrence rates in uncomplicated pregnancies are limited.
Purpose of the Study:
- To determine the recurrence rate of mild fetal pyelectasis in subsequent pregnancies.
- To assess the risk of recurrence compared to fetuses without pyelectasis.
- To explore potential factors influencing recurrence.
Main Methods:
- Prospective study of 420 women with two consecutive uncomplicated pregnancies.
- Ultrasound screening at 15-24 weeks' gestation.
- Pyelectasis defined as fetal renal pelvis anteroposterior dimension ≥ 4 mm.
Main Results:
- 64 fetuses presented with pyelectasis.
- Recurrence was observed in 43 of these fetuses (67%) in their next pregnancy.
- Fetuses with pyelectasis had a 6.1-fold increased risk of recurrence (95% CI: 4.3-7.5, p < 0.001).
Conclusions:
- Mild fetal pyelectasis shows a significant recurrence rate in subsequent pregnancies.
- Findings suggest an underlying predisposition, possibly influenced by genetic or environmental factors.
- Further research is needed to refine risk assessment and management strategies.