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Sexually dimorphic effects of anti-NGF treatment in neonatal rats
L Ricceri1, A Ewusi, G Calamandrei
1Section of Comparative Psychology, Istituto Superiore di Sanità, Rome, Italy.
Brain Research. Developmental Brain Research
|July 18, 1997
Abstract:
This study investigated how chronic perinatal reduction of nerve growth factor (NGF) affected brain cholinergic markers in the two sexes. Rats received anti-NGF on postnatal days (PNDs) 2-12, and choline acetyltransferase (ChAT) activity was measured on PND 16. Anti-NGF significantly reduced cortical ChAT activity in males, but not in females; no sex-dependent effects were found in hippocampus or striatum. These data suggest sexual dimorphism in cholinergic responsiveness to NGF.