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NGF antibodies impair long-term depression at the mossy fibre-CA3 synapse in the developing hippocampus
F Ruberti1, N Berretta, A Cattaneo
1Neuroscience Program, International School for Advanced Studies (SISSA), Trieste, Italy. ruberti@icgeb.trieste.it
Brain Research. Developmental Brain Research
|July 18, 1997
Abstract:
Nerve growth factor (NGF) and other neurotrophins are proteins involved in neuronal survival and differentiation. Much experimental evidence is now drawing attention into a role of neurotrophins in activity-dependent synaptic plasticity processes. We now show that slices from rats chronically deprived of NGF, by intraventricular injection of alpha D11 hybridoma cells, which produce monoclonal antibodies against NGF, display a reduced probability of induction of long-term depression at the mossy fibre-CA3 synapse.