Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endothelin in ischemic acute renal failure

T E Hunley1, V Kon

  • 1Division of Pediatric Nephrology, Vanderbilt University School of Medicine, Nashville, Tenessee 37232-2584, USA.

Current Opinion in Nephrology and Hypertension
|July 1, 1997
PubMed
Summary

Endothelin peptides cause prolonged vasoconstriction, particularly affecting kidney microcirculation after injury. Blocking endothelin improves kidney function following ischemia, highlighting its role in acute renal failure.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Angiotensin receptor blocker vs ACE inhibitor effects on HDL functionality in patients on maintenance hemodialysis.

Nutrition, metabolism, and cardiovascular diseases : NMCD·2018
Same author

Effect of sevelamer hydrochloride exposure on carotid intima media thickness in hemodialysis patients.

Nephron. Clinical practice·2010
Same author

Update on endothelins - biology and clinical implications.

Pediatric nephrology (Berlin, Germany)·2001
Same author

Prospects for gene transfer into renal cells.

Kidney international·2000
Same author

Dual renin gene targeting by Cre-mediated interchromosomal recombination.

Genomics·2000
Same author

The angiotensin type II receptor tonically inhibits angiotensin- converting enzyme in AT2 null mutant mice.

Kidney international·2000

Area of Science:

  • Nephrology
  • Cardiovascular Physiology
  • Molecular Medicine

Background:

  • Endothelin peptides are potent, long-lasting vasoconstrictors.
  • Renal microcirculation is highly susceptible to endothelin.
  • Increased renal endothelin expression follows injurious stimuli like ischemia.

Purpose of the Study:

  • To investigate the role of endothelin in prolonged renal dysfunction after ischemia.
  • To explore the mechanism of autoinduction in endothelin's sustained effects.
  • To determine the impact of endothelin antagonism on postischemic kidney injury.

Main Methods:

  • Assessing renal endothelin expression post-injury.
  • Investigating endothelin autoinduction.
  • Utilizing endothelin antagonists to study effects on glomerular function.

Related Experiment Videos

Main Results:

  • Renal endothelin expression increases after ischemia and persists.
  • Autoinduction is a likely mechanism for prolonged endothelin effects.
  • Antagonizing endothelin ameliorates postischemic glomerular dysfunction.

Conclusions:

  • Endothelin plays a critical role in maintaining renal dysfunction after ischemic injury.
  • Targeting endothelin pathways may be a therapeutic strategy for ischemic acute renal failure.
  • Understanding endothelin's autoinduction is key to managing prolonged vasoconstriction.