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Related Experiment Videos

Bromocriptine enhances feeding behavior without changing dopamine metabolism

K Inoue1, N Kiriike, M Kurioka

  • 1Department of Neuropsychiatry, Osaka City University Medical School, Japan.

Pharmacology, Biochemistry, and Behavior
|September 1, 1997
PubMed
Summary

Bromocriptine enhances feeding behavior by acting on postsynaptic D2 receptors in the rat striatum. This study confirms its selective action without affecting dopamine release, clarifying its mechanism of action.

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Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • Bromocriptine, an ergot derivative, is hypothesized to be a selective D2 receptor agonist.
  • Its in vivo effects on dopamine release remain unconfirmed.

Purpose of the Study:

  • To investigate the effects of bromocriptine on feeding behavior and dopamine release in rats.
  • To determine if bromocriptine acts on postsynaptic D2 receptors.

Main Methods:

  • Bromocriptine was administered into the ventrolateral striatum of rats via microdialysis.
  • Feeding behavior and extracellular dopamine, DOPAC, and HVA concentrations were measured.
  • The effects of (-) sulpiride, a D2 receptor antagonist, were also examined.

Main Results:

  • Bromocriptine increased food intake dose-dependently without altering dopamine, DOPAC, or HVA levels.

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  • (-) Sulpiride decreased food intake and increased dopamine release and metabolite levels.
  • Pre-treatment with (-) sulpiride blocked bromocriptine-induced hyperphagia and increased dopamine release.

    • Conclusions:

    • Bromocriptine directly stimulates postsynaptic D2 receptors in the ventrolateral striatum.
    • This selective action enhances feeding behavior.
    • The findings clarify the mechanism of bromocriptine's effect on appetite.