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Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System
Published on: December 7, 2012
Beditine, a new benzodioxane derivative, as a suppressor of human polymorphonuclear leukocyte and platelet activation
A Panossian1, G Grigorian, S Akopov
1C. Guelbenkian Research Laboratories of the Drug Agency of the Ministry of Health, Yerevan, Armenia. phanos@drag.iiap.sci.am
Biochemical Pharmacology
|June 1, 1997
Abstract:
Beditine, 2-(2-amino-4-thiazolyl)-1,4-benzodioxane hydrochloride is a new substance which reduced platelet activation and degranulation, prevented aggregation and superoxide generation by activated human polymorphonuclear leukocytes (PMNL) and inhibited the activation of arachidonate 5-lipoxygenase. Beditine may, therefore, be a useful agent in the treatment of cardiovascular disease.

