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Angiogenesis in endometrial carcinoma
1Department of Gynecology and Obstetrics, Faculty of Medicine, Kyushu University, Higashi-ku, Fukuoka, Japan.
Cancer
|August 15, 1997
Summary
High microvessel density (MVD) in endometrial tumors indicates a poorer prognosis. This study found MVD to be an independent predictor of progression-free and overall survival in endometrial cancer patients.
Area of Science:
- Oncology
- Pathology
- Angiogenesis Research
Background:
- Tumor angiogenesis is critical for cancer growth and metastasis.
- Microvessel density (MVD) is a key indicator of tumor angiogenesis and has prognostic value.
- Endometrial carcinoma prognosis can be influenced by various clinicopathologic factors.
Purpose of the Study:
- To investigate the relationship between MVD and clinicopathologic parameters in endometrial carcinoma.
- To assess the correlation of MVD with metastasis and survival outcomes in endometrial cancer patients.
Main Methods:
- Histological review of 85 Stage I and II endometrial carcinomas treated with hysterectomy and lymph node dissection.
- Immunohistochemical staining for factor VIII-related antigen to quantify MVD.
- Statistical analysis including Mann-Whitney U, Kruskal-Wallis, Spearman correlation, Kaplan-Meier survival analysis, and Cox proportional hazards model.
Main Results:
- MVD significantly correlated with tumor grade, myometrial invasion, and lymph-vascular space invasion.
- No correlation was observed between MVD and lymph node status or tumor stage.
- High MVD (> or =60) was associated with significantly worse progression-free survival (PFS) and overall survival (OS).
Conclusions:
- Microvessel density (MVD) is a significant independent prognostic factor for PFS and OS in patients with endometrial carcinoma.
- MVD assessment can aid in predicting outcomes for endometrial cancer patients.