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[Epileptic seizures and immune disorders]
V Mokrán1, M Simko, S Nyulassy
1Specializované pracovisko pre záchvatovité choroby II. neurologickej kliniky Lekárskej fakulty Univerzity Komenského v Bratislave, Slovakia.
Bratislavske Lekarske Listy
|April 1, 1997
Summary
Immunity disturbances are prevalent in epilepsy patients, with over 96% showing abnormalities. Immunomodulatory therapy shows promise as a supplementary treatment for epilepsy management.
Area of Science:
- Neurology
- Immunology
Context:
- Epileptic seizures are linked to infections and immunity disturbances.
- Phenytoin, an antiepileptic drug, affects the immune system.
- Approximately 30% of the population experiences immunity disturbances.
Purpose:
- To document immunity disturbances in epilepsy patients (5-25 years) with generalized convulsive epilepsy (GENKONV-GK) and partial epilepsy with complex symptomatology (PARTKOMP-PK).
- To investigate the positive effects of immunomodulatory therapy in these patients.
Summary:
- 125 epilepsy patients (50 GENKONV-GK, 75 PARTKOMP-PK) were studied for immunity disturbances.
- 80-85% of patients exhibited specific cellular immunity disturbances.
- Atopy was observed in 56% (GENKONV-GK) and 65% (PARTKOMP-PK) of patients.
Impact:
- Over 96% of studied epilepsy patients displayed immunity disturbances.
- Immunomodulatory therapy is a promising supplementary treatment for stabilizing epilepsy.