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[Drugs and light]

H H Tønnesen1

  • 1Avdeling for galenisk farmasi, Universitetet i Oslo, Blindern.

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|June 30, 1997
PubMed
Summary
This summary is machine-generated.

Many drugs degrade or cause side effects when exposed to light. This review highlights drug photoreactivity issues and lists photosensitizing drugs to improve patient safety.

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Area of Science:

  • Photochemistry
  • Pharmacology
  • Drug Stability

Context:

  • Increasing number of drugs exhibit photochemical instability or phototoxic potential.
  • Existing handbooks often lack comprehensive photoreactivity data for drugs and drug products.
  • Lack of standardized evaluation methods and official specifications hinders information accessibility.

Purpose:

  • To address the challenges in obtaining drug photoreactivity information.
  • To discuss the implications of drug-light interactions in vitro and in vivo.
  • To highlight the need for more data on drug photoreactivity.

Summary:

  • Drug exposure to light can lead to photodecomposition, reducing potency.
  • Photodegradation products formed during storage and use can cause adverse effects.

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  • Administered drugs can induce light-related side effects such as phototoxicity and photoallergy.

    • Impact:

    • Increased awareness of drug photoreactivity is crucial for minimizing adverse effects.
    • Provides a list of potential photosensitizing drug substances available on the Norwegian market.
    • Emphasizes the need for comprehensive data to ensure safer drug utilization.