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Updated: Aug 11, 2026
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Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
Published on: April 3, 2016
[Effect of active medium on sclera creep]
E D Shchukin1, V N Izmaílova, M M Krasnov
1Moscow State University.
Vestnik Oftalmologii
|May 1, 1997
Summary
High myopia may be caused by irreversible stretching of the eye sclera. Researchers observed enzymes affecting scleral creep, suggesting potential preventive therapies for eye conditions.
Area of Science:
- Ophthalmology
- Biomechanical Engineering
- Biochemistry
Context:
- Scleral creep, the irreversible stretching of the eye's sclera, is a proposed cause of high myopia.
- Connective tissue creep is influenced by mechanical stresses and linked to aging and pathological changes.
- Previous research has explored the biomechanical properties of the sclera.
Purpose:
- To investigate the effect of enzymes on scleral creep.
- To identify potential targets for therapeutic intervention in myopia and other connective tissue disorders.
Summary:
- Experimental studies on bovine sclera demonstrated that certain enzymes can significantly accelerate or decelerate scleral creep.
- This research highlights the role of enzymatic activity in modulating the biomechanical behavior of connective tissues.
- The findings suggest a link between enzymatic processes and the progression of scleral stretching.
Impact:
- Identifying creep inhibitors could lead to non-surgical, preventive treatments for high myopia.
- This approach may offer alternatives to surgical interventions in ophthalmology.
- Potential applications extend to cosmetology for managing age-related connective tissue changes.
