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Related Experiment Videos

Engineering antibodies for imaging and therapy

P Carter1, A M Merchant

  • 1Department of Molecular Oncology, Genentech Inc., South San Francisco, CA 94080, USA. pjc@gene.com

Current Opinion in Biotechnology
|August 1, 1997
PubMed
Summary
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Recent advances in antibody development, including rapid isolation techniques and improved production methods, enhance the potential for new antibody therapies and diagnostics. These innovations support the creation of targeted treatments and imaging agents.

Area of Science:

  • Biotechnology
  • Immunology
  • Pharmaceutical Science

Background:

  • Therapeutic antibody development is crucial for treating various diseases.
  • Past limitations in antibody isolation and production methods have hindered progress.

Purpose of the Study:

  • To highlight recent advancements in therapeutic antibody development.
  • To discuss innovations enhancing antibody isolation, production, and utility.

Main Methods:

  • Rapid isolation of high-affinity human antibodies using phage display libraries.
  • Immunization of transgenic mice for antibody generation.
  • Improved production methods for bispecific antibody fragments and Fc-containing proteins.
  • Development of site-specific labeling for radiolabeled antibody fragments.

Related Experiment Videos

  • Engineering of antibody fragments, such as the 'minibody'.

    • Main Results:

    • Significant progress in rapidly isolating high-affinity human antibodies.
    • Enhanced therapeutic potential of bispecific antibody fragments and Fc-containing proteins due to improved production.
    • Improved utility of radiolabeled antibody fragments through site-specific labeling.
    • Demonstrated success of the 'minibody' fragment for tumor imaging in mice.

    Conclusions:

    • Recent breakthroughs facilitate the development of novel therapeutic antibodies.
    • Innovations in antibody engineering and production expand possibilities for targeted therapies and diagnostics.
    • Engineered antibody fragments show promise for applications like in vivo tumor imaging.