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Efficacy of olanzapine: an overview of pivotal clinical trials
C M Beasley1, G D Tollefson, P V Tran
1Psychopharmacology Division, Eli Lilly and Company, Indianapolis, IN 46285, USA.
The Journal of Clinical Psychiatry
|January 1, 1997
Abstract:
Olanzapine is a new "atypical" antipsychotic agent that belongs chemically to the thienobenzodiazepine class. Its relatively greater binding affinity for 5-HT2 compared to D2 receptors makes it similar to the atypical agent clozapine, a serotonin/dopamine antagonist. Four double-blind pivotal studies, which compare olanzapine to placebo and/or haloperidol, are presented. The results suggest that olanzapine is as effective as haloperidol for positive symptoms and more effective than haloperidol for the treatment of the negative symptoms of schizophrenia.