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[Effect of rapid digitalization on the left-ventricular myocardial function according to the echocardiographic data]
Insights
Rapid digitalization with strophanthin in heart disease patients decreased left ventricular volumes and improved central hemodynamics. The study highlights strophanthin
Area of Science:
- Cardiology
- Pharmacology
Context:
- Echocardiographic evaluation of 61 patients with rheumatic heart disease and atherosclerotic cardiosclerosis.
- Focus on rapid digitalization using intravenous glycosides.
Purpose:
- To investigate the hemodynamic effects of rapid stage-by-stage digitalization with strophanthin.
- To analyze the temporal relationship between inotropic and chronotropic effects of strophanthin.
Summary:
- Rapid strophanthin administration decreased left ventricular volumes and enhanced central hemodynamics.
- Observed increase in stroke volume likely mediated by the Frank-Starling mechanism.
- Strophanthin accelerated myocardial contraction rate and diastolic relaxation, optimizing conditions for subsequent contractions.
Impact:
- Provides insights into the acute effects of strophanthin on cardiac function.
- Suggests potential benefits for managing heart failure patients.
- Contributes to understanding glycoside pharmacology in cardiovascular disease.
Abstract:
The article deals with the data of echocardiographic examination of 61 patients (37 with rheumatic heart disease and 17 with atherosclerotic cardiosclerosis) subjected to rapid stage-by-stage digitalization by intravenous administration of various rapidly acting glycosides. In 10 patients with ischemic heart disease echocardiography was performed following a single strophanthin injection. Decrease in the volumes of the left ventricle and increase in the indices of central hemodynamics were noted as a result of rapid stage-by-stage saturation with strophanthin. The maximum inotropic effect of strophanthin does not coincide in time with the maximum chronotropic effect. The increase in the stroke volume noted in maximum deceleration of cardiac contractions is probably realized due to the Frank-Starling mechanism. Strophanthin increases the rate of myocardial contractions without changing the duration of the systole. The rate of diastolic relaxation grows, the phase of rapid filling becomes shorter and the phase of slow filling longer, which creates favourable conditions for the next contraction.