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Updated: Aug 14, 2026

Pre-clinical Model of Cardiac Donation after Circulatory Death
Published on: August 2, 2019
[Analysis of causes of death of patients with chronic circulatory insufficiency]
Insights
Thromboembolism, particularly pulmonary artery embolism, was the leading cause of death in patients with chronic heart conditions. This complication frequently occurred alongside chronic circulatory insufficiency in heart disease, cardiosclerosis, and myocardiopathy.
Area of Science:
- Cardiology
- Internal Medicine
Context:
- Analysis of 166 patients with rheumatic heart disease, postinfarction cardiosclerosis, and myocardiopathies.
- Focus on patients with Stage III or IIB circulatory insufficiency.
Purpose:
- To identify the primary causes of mortality in patients with chronic heart conditions complicated by circulatory insufficiency.
- To determine the most frequent complications leading to death.
Summary:
- Chronic circulatory insufficiency alone caused death in only one-third of cases.
- Thromboembolism, predominantly pulmonary artery thromboembolism, was the most frequent cause of death in the remaining two-thirds.
- Other causes included pneumonias and gastric ulcer hemorrhages.
Impact:
- Highlights thromboembolism as a critical, often fatal, complication in chronic heart failure patients.
- Informs clinical practice regarding risk factors and preventative strategies for thromboembolic events in cardiology.
- Underscores the need for vigilant monitoring and management of thromboembolic risks in patients with cardiosclerosis and myocardiopathies.
Abstract:
The presented analysis is based on the case reports of 166 patients who had been treated in the A. L. Myasnikov Cardiology Institute, USSR Academy of Medical Sciences, for rheumatic heart diseases (97), postinfarction cardiosclerosis (35), myocardiopathies (24) complicated by Stage III or IIB circulatory insufficiency. Chronic circulatory insufficiency free of complications was the cause of death of only 1/3 of the mortality cases. The rest of the patients' death was considered to be caused by thromboembolism, predominantly to the pulmonary artery system, pneumonias, haemorrhages from acute and subacute gastric ulcers, etc. The factors most frequently complicating the chronic circulatory insufficiency in patients suffering either from heart diseases, cardiosclerosis, or myocardiopathy, were thromboembolisms.
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