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Apoptosis in neurodegenerative disorders

L Stefanis1, R E Burke, L A Greene

  • 1Department of Neurology, Columbia University, New York, USA.

Current Opinion in Neurology
|August 1, 1997
PubMed
Summary

Apoptosis, programmed cell death, is investigated in neurodegenerative diseases. While evidence is mounting, definitive proof of apoptosis

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Area of Science:

  • Neuroscience
  • Cell Biology
  • Pathology

Background:

  • Neurodegenerative diseases are a significant health concern.
  • The role of programmed cell death (apoptosis) in these disorders is under investigation.

Purpose of the Study:

  • To review current research on apoptosis in neurodegenerative diseases.
  • To discuss the evidence supporting apoptosis in various neurological conditions.

Main Methods:

  • Review of recent scientific literature.
  • Analysis of tissue culture models.
  • Examination of animal models.
  • Consideration of human pathological studies.

Main Results:

  • Supportive evidence for apoptosis exists in several neurodegenerative disorders.
  • Evidence is not yet definitive across all studied conditions.

Conclusions:

  • Apoptosis is a potential contributor to neurodegeneration.
  • Further research is needed to definitively establish the role of apoptosis.

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