Sweat gland vacuoles in Unverricht-Lundborg disease

We report a re-evaluation of skin biopsies of 4 patients with Unverricht-Lundborg (UL) disease showing membrane-bound bodies in sweat glands. The previously described findings in 5 patients by Cochius et al. (1994) are confirmed. The data suggest that skin biopsy may be a useful mean for confirmation of diagnosis in this disorder, but the specificity of these findings is to be proved by examination of a larger number of cases.