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[Prognostic implication of DNA contents on long-term outcome of childhood acute lymphoblastic leukemia]
M Tsurusawa1, N Katano, M Aoyama
1Department of Pediatrics, Aichi Medical University.
Insights
Cellular DNA content, specifically the DNA index (DI), helps predict treatment success in childhood acute lymphoblastic leukemia (ALL). Higher DI values correlate with better outcomes, aiding in risk stratification for ALL therapy.
Area of Science:
- Pediatric Oncology
- Hematology
- Molecular Biology
Abstract:
Prognostic value of cellular DNA content was evaluated in 189 children with acute lymphoblastic leukemia. Treatment outcome of the three different DNA index (DI) groups (Group A, DI = 1.0 vs. Group B, DI 1.01-1.15 vs. Group C, DI > or = 1.16) was compared between the two treatment risk groups (standard-risk and high-risk groups) stratified by the initial leukocyte count and age. In the standard-risk group, these groups had 10-year event free survival (EFS) rate (SE) of 62% (6%), 40% (21%) and 87% (6%), respectively (p < 0.05). In the high risk group, they had 10-year EFS rate of 30% (5%), 33% (27%) and 60% (19%), respectively (p < 0.01). Use of the DI, leukocyte count and age may be sufficient to distinguish the patients with an extremely low risk of failing to the standard ALL therapy from the patients with a relatively high-risk of treatment failure.