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Serum angiotensin-converting enzyme in multiple sclerosis

C S Constantinescu1, D B Goodman, R I Grossman

  • 1Department of Neurology, University of Pennsylvania, Philadelphia 19104-4283, USA.

Archives of Neurology
|August 1, 1997
PubMed
Summary

Serum angiotensin-converting enzyme (ACE) activity may indicate multiple sclerosis (MS) disease activity. Elevated ACE levels in MS patients correlated with MRI-detected lesion volume changes.

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Area of Science:

  • Neurology
  • Immunology
  • Biochemistry

Background:

  • Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system.
  • The role of serum angiotensin-converting enzyme (ACE) in MS pathogenesis and activity is not fully understood.

Purpose of the Study:

  • To investigate the prevalence and significance of elevated serum ACE activity in MS patients.
  • To explore the correlation between serum ACE activity and clinical and MRI-based indicators of MS disease activity.

Main Methods:

  • A retrospective cross-sectional and longitudinal study involving 75 MS patients and 31 healthy controls.
  • Serum ACE activity was quantified using a spectrophotometric assay.
  • Correlations were analyzed between ACE activity, clinical disease markers, and total cerebral lesion volume on MRI.

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Main Results:

  • Elevated serum ACE activity was observed in 23% of MS patients compared to 6% of controls.
  • Serum ACE activity changes showed a significant correlation with changes in total brain plaque volume on MRI.

Conclusions:

  • Serum ACE activity may serve as a biomarker for monitoring disease activity in MS over time.
  • Elevated serum ACE in typical MS cases does not necessarily suggest alternative diagnoses.