Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antiviral agents

P E Hermans

    Mayo Clinic Proceedings
    |November 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Limited antiviral drugs exist for clinical use. Amantadine hydrochloride is effective for influenza A2 prophylaxis, while topical idoxuridine and adenine arabinoside treat herpes simplex keratitis.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Risk factors for cytomegalovirus and severe bacterial infections following liver transplantation: a prospective multivariate time-dependent analysis.

    Journal of hepatology·1993
    Same author

    Pneumocephalus due to barotrauma: CT demonstration.

    AJR. American journal of roentgenology·1992
    Same author

    Lack of association between cytomegalovirus infection, HLA matching and the vanishing bile duct syndrome after liver transplantation.

    Hepatology (Baltimore, Md.)·1992
    Same author

    Early diagnosis of cytomegalovirus hepatitis in liver transplant recipients: role of immunostaining, DNA hybridization and culture of hepatic tissue.

    Hepatology (Baltimore, Md.)·1990
    Same author

    Cytomegalovirus hepatitis in liver transplantation: prospective analysis of 93 consecutive orthotopic liver transplantations.

    The Journal of infectious diseases·1989
    Same author

    Bacterial infections after liver transplantation.

    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·1989
    Same journal

    Advancing Pulmonary Fibrosis Care: Integrating Genomic Insights Into Clinical Practice.

    Mayo Clinic proceedings·2026
    Same journal

    RAAS Inhibition in the ICU: Stop, Continue, or Restart?

    Mayo Clinic proceedings·2026
    Same journal

    Chronic Kidney Disease-In the Limelight, July 2026.

    Mayo Clinic proceedings·2026
    Same journal

    In Reply: Long-Term Cardiovascular Burden After Carotid Endarterectomy: Moving Beyond Conventional Risk Profiling.

    Mayo Clinic proceedings·2026
    Same journal

    Long-Term Cardiovascular Burden After Carotid Endarterectomy: Moving Beyond Conventional Risk Profiling.

    Mayo Clinic proceedings·2026
    Same journal

    Real-World Comparative Effectiveness of Tirzepatide and Semaglutide for Obesity: A Multicentered Study.

    Mayo Clinic proceedings·2026
    See all related articles

    Area of Science:

    • Pharmacology
    • Virology
    • Infectious Diseases

    Background:

    • Few antiviral agents are currently approved for widespread clinical application.
    • Antiviral therapies are crucial for managing viral infections, including influenza and herpes viruses.
    • The development of effective antiviral drugs remains a significant challenge in medicine.

    Purpose of the Study:

    • To review the current landscape of antiviral agents available for clinical use.
    • To highlight the efficacy and applications of specific antiviral drugs.
    • To discuss the limitations and ongoing research in antiviral therapy.

    Main Methods:

    • Literature review of existing antiviral medications.
    • Analysis of clinical trial data and established therapeutic uses.

    Related Experiment Videos

  • Evaluation of the spectrum of activity and limitations of key antiviral agents.

    • Main Results:

    • Amantadine hydrochloride demonstrates efficacy in preventing influenza A2.
    • Idoxuridine and adenine arabinoside are effective topical treatments for herpes simplex keratitis.
    • Adenine arabinoside is being investigated for broader applications in herpes infections.
    • Ribavirin's broad in vitro activity has not translated to clinical success.
    • Methisazone's importance has diminished due to smallpox eradication.

    Conclusions:

    • The clinical availability of effective antiviral agents remains limited.
    • Specific antivirals show promise for targeted viral infections like influenza and herpes.
    • Further research is needed to develop broadly effective antiviral therapies.