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Accelerative sliding of myosin-coated glass-beads under suspended condition from actin paracrystal
1Department of Biological Science and Technology, Tokai University, 317 Nishino, Numazu, Shizuoka, 410-03, Japan.
Biochemical and Biophysical Research Communications
|August 18, 1997
Abstract:
The maximum sliding velocity of rabbit skeletal-muscle myosin is about 10 micron/sec under zero load and physiological conditions. We have found, however, that a large glass-bead (diameter, 65 micron) coated by rabbit skeletal myosin slides at 338 +/- 47 micron/sec under a condition suspended from an actin paracrystal surface. Also the sliding velocity increases exponentially as the size of myosin-coated glass-beads increases. We report here that the sliding velocity of myosin can be controlled by the adhesion force and the external normal force acting between actin and myosin.