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Related Experiment Videos

Risperidone in the elderly: a pharmacoepidemiologic study

C A Zarate1, R J Baldessarini, A J Siegel

  • 1Pharmacoepidemiology Center, McLean Hospital, Belmons, MA 02178, USA.

The Journal of Clinical Psychiatry
|July 1, 1997
PubMed
Summary
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Risperidone is effective for elderly psychiatric patients, but caution is needed. Low doses and slow increases are recommended, especially for those with cardiovascular issues or on other medications.

Area of Science:

  • Geriatric Psychiatry
  • Psychopharmacology
  • Neuroleptic Treatment

Background:

  • Interest in risperidone for geriatric patients due to potentially limited adverse effects.
  • Geriatric population often presents with complex medical and psychiatric comorbidities.

Purpose of the Study:

  • To evaluate the efficacy and safety of risperidone in hospitalized psychogeriatric patients.
  • To identify factors associated with risperidone's benefits and adverse events in the elderly.

Main Methods:

  • Retrospective review of medical records for 122 geriatric patients (> or = 65 years old) newly treated with risperidone.
  • Data collected included indications, dosage, efficacy, and adverse events.

Main Results:

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  • Risperidone was effective in 85% of cases for agitation or psychosis associated with dementia or mood disorders.
  • Adverse events (32%) included hypotension, orthostasis, cardiac events, and extrapyramidal effects, particularly in medically ill patients.
  • Discontinuation occurred in 18% due to intolerability or inefficacy.

    • Conclusions:

    • Risperidone can be effective and safe for many elderly psychiatric patients with comorbidities when used at low doses and increased slowly.
    • Caution is advised in patients with cardiovascular disease or those on concomitant psychotropic medications like SRI antidepressants or valproate.