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Endometrial hyperplasia and the risk of endometrial carcinoma
1Department of Gynaecologic Oncology & Urogynaecology, Kandang Kerbau Hospital, Singapore.
Objectives:
To determine the incidence of endometrial carcinoma in endometrial hyperplasia and try to identify those patients at greatest risk.
Methods:
We conducted a retrospective study of 116 patients who had simple, complex or mixed (simple with focal complex) endometrial hyperplasia with or without atypia, from January 1991 to December 1994.
Results:
Twenty-nine patients had endometrial hyperplasia with atypia and 87 without atypia. Incidence of endometrial carcinoma was 27.6% in those with atypia; and 3.4% in those without atypia. All were stage I (A or B) adenocarcinomas. Polycystic Ovary Disease and subfertility were found significantly in the cases with cytological atypia; however, they were not significant in the cases with carcinoma. No significant historical differences that could predict carcinoma were found.