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Ticlopidine induced cholestatic jaundice

H B Yim¹, P K Lieu, P W Choo

¹Department of Geriatric Medicine, Tan Tock Seng Hospital, Singapore.

Singapore Medical Journal

|March 1, 1997

Summary

Ticlopidine hydrochloride, an antiplatelet drug, may rarely cause cholestatic jaundice. This case report highlights a rare but serious side effect of this commonly used medication.

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Area of Science:

Pharmacology
Hepatology
Clinical Medicine

Background:

Ticlopidine hydrochloride is a widely used antiplatelet medication.
It demonstrates significant efficacy in preventing stroke recurrence, potentially exceeding that of aspirin.
Common side effects include gastrointestinal disturbances and blood dyscrasias.

Observation:

A rare case of ticlopidine-induced cholestatic jaundice is presented.
This adverse event is infrequently reported in medical literature.
The patient experienced jaundice as a consequence of ticlopidine hydrochloride administration.

Findings:

Ticlopidine hydrochloride, despite its benefits, carries a risk of rare but severe hepatotoxicity.
Cholestatic jaundice is an identified, albeit uncommon, adverse reaction.
The case underscores the importance of monitoring liver function in patients on ticlopidine therapy.

Implications:

Clinicians should be aware of the potential for ticlopidine-induced cholestatic jaundice.
Early recognition and management are crucial for patients developing jaundice while on ticlopidine.
This case contributes to the understanding of rare adverse drug reactions in antiplatelet therapy.

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