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Related Experiment Videos

Multiorgan system failure caused by valproic acid toxicity

R Pinkston1, L A Walker

  • 1Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

The American Journal of Emergency Medicine
|September 1, 1997
PubMed
Summary

Valproic acid, an antiseizure drug, can cause severe liver injury. This report details a rare case of adult valproic acid toxicity leading to multiorgan failure, from which the patient survived.

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Area of Science:

  • Pharmacology
  • Toxicology
  • Neurology

Background:

  • Valproic acid is a widely used medication for epilepsy and migraine prophylaxis.
  • Hepatotoxicity is a known adverse effect of valproic acid, ranging from mild to fatal idiosyncratic reactions.
  • Multisystem toxicity from valproic acid in adults is not well-documented.