Related Experiment Videos
The genetics of psoriasis
1Department of Dermatology, University of Kiel, Germany.
Journal of the American Academy of Dermatology
|August 1, 1997
Summary
Psoriasis susceptibility is linked to human leukocyte antigen (HLA) genes on chromosome 6, with distinct subtypes identified. Genetic and environmental factors contribute to this complex polygenic inherited disease.
Area of Science:
- Genetics
- Immunology
- Dermatology
Background:
- Psoriasis susceptibility is associated with the major histocompatibility complex (MHC) on human chromosome 6.
- Studies suggest psoriasis comprises two subtypes (Type I and Type II) with differing HLA frequencies and onset ages.
Purpose of the Study:
- To investigate the genetic basis of psoriasis, including the role of human leukocyte antigen (HLA) haplotypes and other susceptibility loci.
- To differentiate between psoriasis subtypes based on genetic markers and clinical presentation.
Main Methods:
- Analysis of population-specific human leukocyte antigen (HLA) haplotypes.
- Genome-wide microsatellite marker analysis in affected families.
- Review of existing linkage studies for psoriasis susceptibility genes.
Main Results:
- Strong associations found between specific HLA alleles (Cw6, B57, DR7 for Type I; Cw2 for Type II) and psoriasis subtypes.
- Evidence suggests a polygenic inheritance pattern for psoriasis, with potential loci on chromosomes 1, 6, and 17.
- Conflicting results exist for linkage on chromosome 17, while chromosome 4 has been recently implicated.
Conclusions:
- Psoriasis is a polygenetically inherited disease influenced by both genetic factors, particularly HLA, and environmental triggers.
- Distinct genetic profiles may underlie different psoriasis subtypes, impacting disease onset and characteristics.