Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Conceptual apraxia from lateralized lesions

K M Heilman1, L M Maher, M L Greenwald

  • 1Department of Neurology, University of Florida College of Medicine, USA.

Neurology
|August 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Vertical pseudoneglect: Sensory-attentional versus action-intentional.

Journal of clinical and experimental neuropsychology·2022
Same author

Unilateral Apraxic Agraphia without Ideomotor Apraxia from a callosal lesion in a patient with Marchiafava-Bignami disease.

Neurocase·2018
Same author

The visual kinetic depth effect is altered with Parkinson's disease.

Parkinsonism & related disorders·2017
Same author

A full-brain, bootstrapped analysis of diffusion tensor imaging robustly differentiates Parkinson disease from healthy controls.

Neuroinformatics·2014
Same author

The role of cognitive models in language rehabilitation.

NeuroRehabilitation·2014
Same author

Praxis performance with left versus right hemisphere lesions.

NeuroRehabilitation·2014

Patients with Alzheimer's disease exhibit conceptual apraxia (CA), impacting tool knowledge. This study found that conceptual praxis representations are primarily stored in the left hemisphere, distinct from language and motor functions.

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Neurology

Background:

  • Praxis models involve production and conceptual components.
  • Conceptual praxis disorders affect associative (tool-action/object) and mechanical knowledge.
  • Alzheimer's disease patients show conceptual apraxia (CA), separable from language and motor deficits.

Purpose of the Study:

  • To determine if conceptual praxis knowledge is lateralized to a specific hemisphere.
  • To investigate if associative and mechanical conceptual praxis knowledge can be dissociated.
  • To explore the neural basis of conceptual apraxia.

Main Methods:

  • Studied 29 right-handed subjects with unilateral strokes (left or right hemisphere damage).
  • Included groups with and without ideomotor apraxia, plus right-hemisphere and normal controls.

Related Experiment Videos

  • Administered conceptual apraxia tests assessing associative and mechanical knowledge.

    • Main Results:

    • Left-hemisphere damaged patients with ideomotor apraxia showed the most significant impairment on both associative and mechanical CA tests.
    • A trend suggested dissociation between associative and mechanical conceptual praxis knowledge.
    • Conceptual praxis representations appear to be stored in the left hemisphere.

    Conclusions:

    • Conceptual praxis knowledge is primarily localized in the left hemisphere.
    • This knowledge is distinct from verbal semantics and motor representations.
    • Further research is needed to pinpoint the exact location within the left hemisphere.