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CD4 memory T cell levels predict life span in genetically heterogeneous mice

R A Miller¹, C Chrisp, A Galecki

¹Department of Pathology, Institute of Gerontology, Ann Arbor DVA Medical Center, University of Michigan 48109-0642, USA.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology

|August 1, 1997

Summary

Higher levels of CD4 memory T cells in mice predict a longer lifespan. This finding suggests CD4 memory cells may be a biomarker for aging processes or disease predisposition.

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Area of Science:

Immunology
Gerontology
T cell biology

Background:

Aging alters T cell subset proportions, increasing memory cells and P-glycoprotein expression.
Individual differences in T cell subsets may influence longevity.

Purpose of the Study:

To investigate if T cell subset levels predict lifespan in mice.
To identify specific T cell subsets associated with longevity.

Main Methods:

Measured five age-sensitive T cell subsets in mice at 8 and 18 months.
Utilized genetically heterogeneous mice (CB6F1 x C3D2F1).
Performed univariate and multiple regression analyses to correlate T cell levels with lifespan.

Main Results:

Proportion of CD4 memory T cells at 18 months was the strongest predictor of lifespan (P=0.003).

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CD4 memory cell levels strongly correlated with lifespan even after adjusting for sex (P<0.0003).

CD4 cells expressing P-glycoprotein also correlated with lifespan in male mice (P<0.01).

Conclusions:

CD4 memory T cell levels are a significant predictor of lifespan in mice.
Further research is needed to determine if high CD4 memory cells cause disease or are a biomarker of aging.