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Updated: Aug 27, 2026
Methods to Inhibit Bacterial Pyomelanin Production and Determine the Corresponding Increase in Sensitivity to Oxidative Stress
Published on: August 31, 2015
A study of purified pyorubrin produced by local Pseudomonas aeruginosa
S A Kandela1, A S al-Shibib, B H al-Khayat
1Saddam College of Medicine, Baghdad, Iraq.
Abstract:
A study of more than one thousand strains of local P. aeruginosa was performed. These include the strains production of various pigments, methods of extraction and purification, the pigments activity and characteristics. Lately, we have reported a comprehensive study about the purified blue pyocyanine pigment. This paper displays a parallel study of a number of physical and chemical properties of the purified pink pigment, the pyorubrin, that is produced by our local collection of P. aeruginosa strains. This characteristics is useful for production of an active pigment purpose and is necessary in the pigment use as antibiotic, in addition of importance in developing the methods of strains identification. Such studies are important due to the biological significance of pyorubrin activity against other bacteria and in comparison with some known antibiotics; stability tests and MIC (minimum inhibitory concentration) measurements indicate that found isolates were of animal and food origin mainly.
