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Pertussis: a worldwide problem

B Ivanoff1, S E Robertson

  • 1Global Programme for Vaccines and Immunization, World Health Organization, Geneva, Switzerland.

Developments in Biological Standardization
|January 1, 1997
PubMed

Insights

Pertussis vaccination significantly reduces disease incidence, especially in infants. Global efforts aim to increase diphtheria-tetanus-pertussis (DTP) vaccine coverage to 90% to prevent millions of cases.

Area of Science:

  • Pediatrics
  • Immunology
  • Public Health

Background:

  • Pertussis (whooping cough) poses a severe threat to children globally, particularly in developing nations.
  • Infants face the highest risks of severe disease, complications, and mortality from pertussis.
  • Adults may experience mild or asymptomatic pertussis, acting as reservoirs for disease transmission.

Purpose of the Study:

  • To highlight the impact of pertussis vaccination on disease prevention.
  • To emphasize the World Health Organization's (WHO) recommendations for DTP vaccination schedules.
  • To assess progress and identify challenges in achieving global immunization coverage targets.

Main Methods:

  • Analysis of pertussis incidence, complication rates, and case fatality rates.
  • Review of global immunization coverage data for diphtheria-tetanus-pertussis (DTP) vaccine.
  • Examination of WHO's recommended vaccination schedules and coverage goals.

Main Results:

  • Whole cell pertussis vaccine prevented an estimated 70 million cases in 1994.
  • Despite high vaccination rates (nearly 80% of infants receiving three DTP doses by age one), 40 million pertussis cases occurred in 1994.
  • Significant progress has been made, but challenges remain in achieving universal immunization.

Conclusions:

  • Early completion of the primary DTP vaccination series is crucial for infant protection.
  • Achieving 90% global infant immunization coverage by 2000 requires enhanced immunization programs.
  • Continued efforts are necessary to control pertussis transmission and reduce disease burden worldwide.

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