Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clinical evaluation of Asaley

G P Bodey, J A Gottlieb, M A Burgess

    Medical and Pediatric Oncology
    |January 1, 1977
    PubMed
    Summary

    Asaley, an L-leucine derivative, showed antitumor activity in patients with various cancers. An oral dose of 800 mg/M2/day for 4 days was established, with myelosuppression and nausea as primary toxicities.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Serious complications of vascular catheter-related Staphylococcus aureus bacteremia in cancer patients.

    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·1992
    Same author

    Infectious complications of indwelling vascular catheters.

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1992
    Same author

    Viral pneumonia in the immunocompromised adult with neoplastic disease: the role of common community respiratory viruses.

    Seminars in respiratory infections·1992
    Same author

    Lack of activity of amphotericin B in systemic murine fusarial infection.

    The Journal of infectious diseases·1992
    Same author

    Evaluation of strategies for central venous catheter replacement.

    Critical care medicine·1992
    Same author

    Septicemia and shock syndrome due to viridans streptococci: a case-control study of predisposing factors.

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1992

    Area of Science:

    • Oncology
    • Pharmacology
    • Cancer Research

    Background:

    • Asaley is an L-leucine derivative of sarcolysin with demonstrated activity against rodent tumors.
    • Previous studies in the USSR indicated potential efficacy in ovarian and breast carcinoma, Hodgkin's disease, and multiple myeloma.

    Purpose of the Study:

    • To evaluate the efficacy and toxicity of Asaley in patients with advanced malignancies.
    • To determine an appropriate oral dosage regimen for Asaley administration.

    Main Methods:

    • A study involving 73 evaluable patients with various types of cancer.
    • Oral administration of Asaley at a dose of 800 mg/M2/day for 4 days at 5-6 week intervals for patients with adequate bone marrow.
    • Monitoring for antitumor activity and toxicities.

    Main Results:

    • Antitumor activity was observed in 2 of 24 evaluable melanoma patients.
    • Disease stabilization was noted in patients with adenocarcinoma of the colon, multiple myeloma, lymphoma, breast carcinoma, and thyroid carcinoma.
    • The most frequent toxicities included myelosuppression, nausea, and vomiting.

    Conclusions:

    • Asaley demonstrated minimal and short-duration responses in heavily pre-treated patients.
    • An oral dose of 800 mg/M2/day for 4 days at 5-6 week intervals is suggested for patients with adequate bone marrow.
    • Further investigation may be warranted, considering the observed toxicities and limited efficacy.

    Related Experiment Videos