Related Experiment Videos
[Factor V Leiden and activated protein C resistance]
1Laboratoire de Biologie Médicale-Hématologie CHU André Vésale, Montigny-le-Tilleul.
Revue Medicale De Bruxelles
|June 1, 1997
Summary
Factor V Leiden is the most common inherited thrombophilia, caused by a mutation leading to resistance to activated protein C. Screening is available, but its systematic use in at-risk individuals is debated.
Area of Science:
- Genetics
- Hematology
Context:
- Factor V Leiden is a common inherited thrombophilia.
- It is characterized by a specific point mutation.
- This mutation causes resistance to activated protein C (APC).
Purpose:
- To explain the genetic basis of Factor V Leiden.
- To highlight its significance as a thrombophilic disorder.
- To discuss the implications for clinical screening.
Summary:
- Factor V Leiden is the most frequent inherited thrombophilic disorder, resulting from a point mutation.
- This mutation impairs the inhibition of activated factor V by activated protein C (APC resistance).
- It is prevalent in 20% of patients with venous thrombotic disease and 4% of the general Belgian population.
Impact:
- Factor V Leiden is a significant risk factor for venous thromboembolism.
- Its high prevalence allows for frequent co-occurrence with other thrombophilic conditions.
- The availability of diagnostic tests prompts discussion on systematic screening protocols.