Novel bioreductive anticancer agents based on indolequinones

Cosmological Constraints from Multiple Probes in the Dark Energy Survey.

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Gliotoxin is a dual inhibitor of farnesyltransferase and geranylgeranyltransferase I with antitumor activity against breast cancer in vivo.

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Characterization of a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1 by biochemical, X-ray crystallographic, and mass spectrometric approaches.

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Structure-based development of anticancer drugs: complexes of NAD(P)H:quinone oxidoreductase 1 with chemotherapeutic quinones.

Structure (London, England : 1993)·2001

Indolequinone antitumor agents: correlation between quinone structure and rate of metabolism by recombinant human NAD(P)H:quinone oxidoreductase. Part 2.

Journal of medicinal chemistry·2001

Relationship between NAD(P)H:quinone oxidoreductase 1 (NQO1) levels in a series of stably transfected cell lines and susceptibility to antitumor quinones.

Biochemical pharmacology·2001

Chemical and biochemical transformations of 5-ethoxycarbonyl-5-phenyl-2-isoxazolines.

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Nasal administration of heparin-loaded microspheres based on poly(lactic acid).

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New 8-substituted xanthiene derivatives as potent bronchodilators.

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In situ and in vivo efficacy of peroral absorption enhancers in rats and correlation to in vitro mechanistic studies.

Farmaco (Societa chimica italiana : 1989)·2005

Synthesis of 3-aryl-5-decapentyl-1,2,4-oxadiazoles possessing antiinflammatory and antitumor properties.

Farmaco (Societa chimica italiana : 1989)·2005

Syntheses, in vitro antibacterial and antifungal activities of a series of N-alkyl, 1,4-dithiines.

Farmaco (Societa chimica italiana : 1989)·2005

Structure-activity profiling of indazole-based derivatives as spinster homolog 2 (Spns2)-dependent S1P release inhibitors.

Bioorganic & medicinal chemistry letters·2026

Triterpenoids and lignans from the stems of Tripterygium wilfordii and their hepatoprotective activities.

Fitoterapia·2026

An integrated in vitro and in silico approach to evaluate the safety and wound healing potential of Dracocephalum moldavica L. seed oil.

Toxicology in vitro : an international journal published in association with BIBRA·2026

Unraveling the allosteric inhibition mechanism of TLR2 by CU-CPT22: A combined DFT and enhanced sampling MD study.

Journal of molecular graphics & modelling·2026

Discovery of pyrimidine-based dual CDK2/TrkA inhibitors: Synthesis, antiproliferative activity, and mechanistic insights.

Bioorganic chemistry·2026

Oleanolic acid-selenocyanate hybrids trigger replication-associated DNA damage responses and suppress tumour growth in vitro and in vivo.

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Novel bioreductive anticancer agents based on indolequinones

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Cosmological Constraints from Multiple Probes in the Dark Energy Survey.

Gliotoxin is a dual inhibitor of farnesyltransferase and geranylgeranyltransferase I with antitumor activity against breast cancer in vivo.

Characterization of a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1 by biochemical, X-ray crystallographic, and mass spectrometric approaches.

Structure-based development of anticancer drugs: complexes of NAD(P)H:quinone oxidoreductase 1 with chemotherapeutic quinones.

Indolequinone antitumor agents: correlation between quinone structure and rate of metabolism by recombinant human NAD(P)H:quinone oxidoreductase. Part 2.

Relationship between NAD(P)H:quinone oxidoreductase 1 (NQO1) levels in a series of stably transfected cell lines and susceptibility to antitumor quinones.

Chemical and biochemical transformations of 5-ethoxycarbonyl-5-phenyl-2-isoxazolines.

Nasal administration of heparin-loaded microspheres based on poly(lactic acid).

New 8-substituted xanthiene derivatives as potent bronchodilators.

In situ and in vivo efficacy of peroral absorption enhancers in rats and correlation to in vitro mechanistic studies.

Synthesis of 3-aryl-5-decapentyl-1,2,4-oxadiazoles possessing antiinflammatory and antitumor properties.

Syntheses, in vitro antibacterial and antifungal activities of a series of N-alkyl, 1,4-dithiines.

Structure-activity profiling of indazole-based derivatives as spinster homolog 2 (Spns2)-dependent S1P release inhibitors.

Triterpenoids and lignans from the stems of Tripterygium wilfordii and their hepatoprotective activities.

An integrated in vitro and in silico approach to evaluate the safety and wound healing potential of Dracocephalum moldavica L. seed oil.

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Novel bioreductive anticancer agents based on indolequinones

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