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Curing children with leukemia in West Virginia

A K Ritchey1, K A Starling, F G Keller

  • 1West Virginia University School of Medicine, Morgantown, USA.

The West Virginia Medical Journal
|July 1, 1997
PubMed
Summary

Childhood leukemia outcomes in West Virginia are promising. Most children with B-lineage acute lymphoblastic leukemia (ALL) treated by pediatric oncology teams achieved long-term remission, indicating high curability.

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Area of Science:

  • Pediatric Oncology
  • Hematology
  • Cancer Research

Background:

  • Leukemia is the most common childhood cancer, with acute lymphoblastic leukemia (ALL) being the most frequent subtype.
  • Historically fatal, leukemia is now highly curable with modern treatments.
  • Understanding regional treatment outcomes is crucial for improving pediatric cancer care.

Purpose of the Study:

  • To evaluate the treatment outcomes for children and adolescents diagnosed with B-lineage ALL in West Virginia.
  • To compare these outcomes with national data for childhood leukemia.

Main Methods:

  • A retrospective analysis was conducted on patients diagnosed with B-lineage ALL between February 1986 and January 1991.
  • Patients were treated by pediatric oncology teams in Morgantown and Charleston, West Virginia, adhering to a uniform treatment protocol.

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Main Results:

  • Out of 41 identified patients, 29 (71%) achieved disease-free survival for over two years post-therapy, considered cured.
  • Five of the 10 patients who relapsed are now disease-free after rescue therapy, indicating potential cures.
  • An overall survival rate of 85% was observed, with 35 out of 41 children alive and disease-free.

Conclusions:

  • Treatment outcomes for childhood ALL in West Virginia are comparable to national averages.
  • Pediatric oncology team-based treatment in West Virginia offers a high probability of cure for children with ALL.
  • This study highlights the effectiveness of standardized treatment protocols in achieving favorable outcomes for pediatric leukemia.