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Published on: December 15, 2011
Measles virus serology in Crohn's disease
N C Fisher1, L Yee, P Nightingale
1Department of Gastroenterology, Staffordshire General Infirmary.
Gut
|July 1, 1997
Summary
This study investigated if early-life measles virus infection predisposes individuals to Crohn's disease. Researchers found no supportive evidence linking measles virus to the development of Crohn's disease.
Area of Science:
- Gastroenterology
- Virology
- Immunology
Background:
- Emerging evidence suggests a potential link between early-life measles virus infection and an increased risk of developing Crohn's disease.
- Investigating this association is crucial for understanding Crohn's disease etiology.
Purpose of the Study:
- To serologically examine the potential association between measles virus infection in early life and Crohn's disease predisposition.
- To analyze antibody titers for measles virus, cytomegalovirus (CMV), adenovirus, and herpes simplex virus (HSV) in Crohn's disease patients and healthy controls.
Main Methods:
- Prospective study involving 45 Crohn's disease patients and 45 healthy controls.
- Serum antibody titers were measured using complement fixation test (CFT) and enzyme-linked immunosorbent assay (ELISA).
- Clinical data and measles virus IgM levels were assessed.
Main Results:
- Reciprocal CFT titers for measles virus were significantly lower in Crohn's disease patients compared to controls (p < 0.05).
- No significant differences were observed in antibody titers for CMV, adenovirus, or HSV between groups.
- No evidence of acute measles virus infection or correlation between measles virus titers and clinical features was found.
Conclusions:
- The study did not find supportive evidence for a role of measles virus in the etiology of Crohn's disease.
- Further research may be needed to explore other potential environmental or genetic factors contributing to Crohn's disease development.
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