Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Delayed postburn blisters: an immunohistochemical and ultrastructural study

R Bergman1, R David, Y Ramon

  • 1Department of Dermatology, Rambam Medical Center, Haifa, Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Israel.

Journal of Cutaneous Pathology
|August 1, 1997
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Breeding for thermotolerance in dairy cattle: Production versus fertility traits.

Journal of dairy science·2025
Same author

Climate resilience differs across dairy sheep populations in Europe.

Animal : an international journal of animal bioscience·2025
Same author

Characterization of bacterial communities of ewe's vaginal tract and its potential impact on reproductive efficiency.

Animal microbiome·2025
Same author

Influence of liquid extender, preservation temperature and time on the sheep sperm quality.

Reproduction in domestic animals = Zuchthygiene·2024
Same author

Efficacy and safety of piclidenoson in plaque psoriasis: Results from a randomized phase 3 clinical trial (COMFORT-1).

Journal of the European Academy of Dermatology and Venereology : JEADV·2024
Same author

Are farmers motivated to select for heat tolerance? Linking attitudinal factors, perceived climate change impacts, and social trust to farmers' breeding desires.

Journal of dairy science·2023

Delayed postburn blistering involves basement membrane discontinuity. This defect in the skin

Area of Science:

  • Dermatology
  • Pathogenesis Research
  • Skin Grafting

Background:

  • Delayed postburn blistering is a complication following skin grafting.
  • The precise pathogenesis of this condition remains incompletely understood.
  • Understanding basement membrane integrity is crucial for healing.

Purpose of the Study:

  • To investigate the ultrastructural and immunohistochemical basis of delayed postburn blistering.
  • To elucidate the role of the basement membrane in blister formation after burns.
  • To identify potential defects in basement membrane components.

Main Methods:

  • Ultrastructural analysis of blister roof and floor.
  • Immunohistochemical staining using antibodies against basement membrane components (laminin, laminin 5, collagen IV, collagen VII).

Related Experiment Videos

  • Comparison of affected blistered skin with adjacent non-blistered healed skin.

    • Main Results:

    • Basement membrane was primarily located on the blister roof, often showing discontinuity.
    • Adjacent healed skin typically exhibited a continuous basement membrane with anchoring fibrils.
    • Immunostaining revealed discontinuity of basement membrane components in blister roofs and sometimes in floors.

    Conclusions:

    • Basement membrane discontinuity is a key anomaly in delayed postburn blistering.
    • Defects in basement membrane component reassembly or local breakdown may underlie this condition.
    • Further research into basement membrane dynamics is warranted.