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Relationship between some humoral factors and left ventricular hypertrophy in essential hypertension
1Department of Cardiovascular Medicine, Electric Power General Hospital, Beijing.
Insights
In essential hypertension, elevated parathyroid hormone (PTH), angiotensin II (ATII), and aldosterone (ALD) are linked to left ventricular hypertrophy (LVH). PTH showed the strongest correlation with left ventricular mass index (LVMI).
Area of Science:
- Cardiology
- Endocrinology
- Hypertension Research
Background:
- Essential hypertension (EH) is a major risk factor for cardiovascular complications, including left ventricular hypertrophy (LVH).
- The renin-angiotensin-aldosterone system (RAAS) is implicated in the pathogenesis of LVH.
- The role of other humoral factors, such as parathyroid hormone (PTH), in cardiac hypertrophy requires further elucidation.
Purpose of the Study:
- To investigate the association between specific humoral factors and the presence of LVH in patients with essential hypertension.
- To compare levels of PTH, angiotensin II (ATII), and aldosterone (ALD) in hypertensive patients with and without LVH.
Main Methods:
- A case-control study involving 62 essential hypertension patients and 20 healthy normotensive controls.
- Patients were stratified into LVH and non-LVH groups based on echocardiographic findings.
- Serum levels of PTH, ATII, and ALD were quantified using radioimmunoassay.
Main Results:
- Significant differences in PTH, ATII, and ALD levels were observed between EH patients and controls.
- Patients with LVH exhibited significantly elevated levels of PTH, ATII, and ALD compared to those without LVH.
- Left ventricular mass index (LVMI) showed significant positive correlations with ATII (r=0.342), ALD (r=0.356), and particularly PTH (r=0.422).
Conclusions:
- Humoral factors, including the RAAS components and PTH, are significant determinants of left ventricular mass.
- Beyond the RAAS, PTH emerges as a potentially crucial factor contributing to cardiac hypertrophy in essential hypertension.
- These findings suggest novel therapeutic targets for managing LVH in hypertensive individuals.
Objective:
To evaluate the relationship between certain humoral factors and left ventricular hypertrophy (LVH) in essential hypertension.
Patients And Methods:
62 essential hypertension (EH) patients (32 men, 30 women; mean age, 55 years) and 20 normotensive healthy subjects (10 men, 10 women: mean age, 52 years) were studied. EH patients were divided into LVH group and non-LVH group by echocardiography. After an overnight fast, blood samples were taken for the determination of parathyroid hormone (PTH), angiotensin II (ATII) and aldosterone (ALD) by radioimmunoassay.
Results:
There was a significant difference in PTH. AT II and ALD between the EH group and control group. Furthermore, in LVH group PTH, ATII and ALD elevated significantly as compared with non-LVH group. In addition, we found that LVMI (left ventricular mass index) correlated with ATII (r = 0.342, P < 0.01) and ALD (r = 0.356, P < 0.01). There was a more significant correlation between LVMI and PTH (r = 0.422, P < 0.0025).
Conclusions:
Some humoral factors are important determinants of LV mass. Besides the reninangiotensin-aldosterone system, PTH might play an important role in cardiac hypertrophy.