Related Experiment Videos
[The immuno-pathological damage of placenta and its types in pregnancy induced hypertension]
Objective:
To study the immuno-pathological damage to placenta and its types in pregnancy induced hypertension (PIH).
Methods:
Using immunohistochemical technique (PAP method), authors studied the expression and localization of IgG, IgE, C3, C4, 5-HT on the villous vessels wall in PIH patients (n = 22) and normal pregnant women (n = 10), and observed the pathological changes of placenta with mast cell and connective tissue stain.
Results:
The immunostaining of IgG, IgE, C3, C4, and 5-HT were seen in the wall of villous vessels in PIH patients, the strong positive rate were 100%, 90%, 100%, 100%, 90% in severe PIH patients respectively, accompanied by aggregation of mast cells and lesions of villi and villous arterioles.
Conclusion:
The immunological compound reaction and types 1, N of anaphylactic reactions took place in the placenta of PIH patients. It showed that the immunological factors were closely related to PIH.