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[The changes in plasma nitric oxide level in normal pregnant women and pregnancy induced hypertension]
Objective:
To investigate the relationship between nitric oxide (NO) level and pregnancy induced hypertension (PIH).
Methods:
The plasma level of NO in 36 cases of normal pregnant women (normal pregnancy group), 23 cases of PIH (PIH group), and 16 cases of non-pregnant women (control group) were measured and compared using fluorophotometry.
Results:
The NO level of normal pregnancy group was significantly higher than that of control group (P < 0.01), particularly in the second trimester of pregnancy. The NO level of PIH was significantly lower than that of third trimester of normal pregnancy (P < 0.01), and it decreased as the disease became severe.
Conclusions:
Decreased synthesizing and releasing of NO might play an important role in pathogenesis of PIH.