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[Expression of thyrotropin receptor gene in autoimmune thyroid disease and the relation to expression of HLA genes]
1Department of Endocrinology, First Teaching Hospital, Beijing Medical University.
Zhonghua Yi Xue Za Zhi
|October 1, 1996
Abstract
Objective:
To investigate the expression of TSH receptor in autoimmune thyroid disease (AITD) and the relation to expression of HLA I and II genes.
Methods:
The TSH receptor transcript levels were examined in 10 human thyroid fragments by Northern blot analysis. Graves' disease 7, Hashimoto's disease 2, and 1 healthy thyroid gland.
Results:
TSH receptor transcript levels were higher in Graves' disease than in Hashimoto's disease and healthy control.
Conclusion:
TSH receptor expression was inversely related to HLA I and II expression and lymphocyte infiltration.