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[Therapeutic effect of trace element on ulcerative colitis experimental study]
Zhonghua Yi Xue Za Zhi
|October 1, 1996
Summary
Combined zinc and selenium therapy effectively treats ulcerative colitis (UC) in rats. This treatment enhances antioxidant activity, increases mineral levels, and improves immune function, offering a potential therapeutic strategy for UC.
Area of Science:
- Gastroenterology
- Nutritional Science
- Immunology
Context:
- Ulcerative colitis (UC) is a chronic inflammatory bowel disease with limited therapeutic options.
- Trace elements play crucial roles in maintaining cellular function and immune homeostasis.
- Investigating novel therapeutic approaches for UC is essential.
Purpose:
- To establish a chronic UC rat model.
- To evaluate the therapeutic efficacy of combined zinc and selenium administration in this model.
- To elucidate the underlying mechanisms of action for zinc and selenium in UC treatment.
Summary:
- Dextran sulfate sodium (DSS) induced UC in male Wistar rats.
- Rats were treated with selenium, zinc plus selenium (ZS), dexamethasone (positive control), or placebo.
- Therapeutic effects were assessed via endoscopic and histologic scoring, and measurement of mucosal SOD activity, MDA content, zinc and selenium levels, and peripheral blood NK activity.
Impact:
- Combined zinc and selenium therapy demonstrated significant efficacy in treating UC, comparable to dexamethasone.
- This treatment upregulated antioxidant enzymes (SOD), reduced lipid peroxidation (MDA), and increased local zinc and selenium concentrations.
- The therapy also enhanced peripheral blood NK cell activity, suggesting an improved immunosurveillance system.