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Updated: Jul 14, 2026
2-Vessel Occlusion/Hypotension: A Rat Model of Global Brain Ischemia
Published on: June 22, 2013
[Regional brain calcium change in rabbit cerebral ischemia]
Objective:
To study whether regional brain calcium change would be an important factor for ischemic neuranal damage and whether calcium antagonist would exert protective effects on cerebral ischemia.
Methods:
OCPC autoanalyzer method, was used to measure the regional brain calcium and observe the influence of flunarizine (FNZ) 48 hours after the rabbit middle cerebral artery occlusion (MCAO).
Results:
48 hours after MCAO, the calcium in the ischemic middle cerebral artery territory was 10.8 times as much as that in the pseudo-occluded controls, and FNZ could significantly decrease the ischemic brain calcium (P < 0.05) and the ischemic cerebral edema (P < 0.01).
Conclusion:
Caoverload was animportant factor leading to ischemic neuronal death, and FNZ has protective effects on cerebral ischemia.
