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[Immunotactoid glomerulopathy]
Objective:
To describe 3 patients with immunotactoid glomerulopathy (IT) and their clinicopathological features.
Methods:
Renal biopsies were examined by EM: they were collected during the last 3 years in Department of Nephrology, First Hospital of Beijing Medical University. The amyloidosis, fibrillary glomerulopathy (FGP) and other systemic disease were excepted by clinical analysis, LM, IF, Congo red staining and image pattern analysis.
Results:
The ultrastructural characteristic of the three cases were microtubular fibrils (diameter: 35-47 nm) deposited in various sites of glomeruli (GBM, subendothelium and mesangium) and electron dense deposits. In addition, randomly fibrillary deposits (diameter: 20 nm) were also found. The fibrils were negative with Congo red staining. The 3 patients were young middle-aged men with proteinuria, microscopic hematuria and hypertension, two of them had renal insufficiency.
Conclusions:
IT is a rare nephropathy but exists in China. Our, patients, were younger Than reported and there prognosis were poor. The microtubular and fibrillary deposits appear in some cases, indicating that IT and FGP are different subtypes of an entity.