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Polyethylene glycol-induced calcium appetite

¹Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104-3308, USA.

The American Journal of Physiology

|August 1, 1997

Summary

Polyethylene glycol (PEG) treatment in rats induced a specific appetite for calcium and sodium. This suggests PEG affects calcium homeostasis, leading to increased intake of calcium solutions.

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Area of Science:

Physiology
Neuroscience
Endocrinology

Background:

Polyethylene glycol (PEG) is used to study sodium intake by reducing extracellular fluid (ECF) sodium.
It is hypothesized that PEG may also affect ECF calcium levels, influencing calcium intake.

Purpose of the Study:

To investigate if PEG administration induces a calcium appetite in rats.
To explore the physiological mechanisms underlying PEG-induced mineral intake.

Main Methods:

Male Sprague-Dawley rats were given two-bottle choice tests with various taste solutions and water after PEG injection.
Plasma mineral concentrations and hormone levels were measured 24 hours post-injection.

Main Results:

PEG-injected rats showed significantly increased intake of low to moderate concentrations of calcium (CaCl2, calcium lactate) and strontium chloride solutions.
Increased intake was also observed for concentrated NaCl and KHCO3, but not for KCl, NH4Cl, AlCl3, FeCl2, or high concentration CaCl2.
Plasma ionized calcium levels decreased, while parathyroid hormone and calcitonin levels increased post-PEG injection.

Conclusions:

Polyethylene glycol (PEG) treatment induces a specific appetite for calcium and sodium in rats.
Reduced plasma ionized calcium and altered hormone levels suggest a role for calcium homeostasis disruption.
PEG's effect extends beyond sodium, influencing calcium intake regulation.

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