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Related Experiment Videos

Relation between optical density at 650 nm and L/S ratios

A J Sbarra, H Michlewitz, R J Selvaraj

    Obstetrics and Gynecology
    |December 1, 1977
    PubMed
    Summary

    A new rapid test for amniotic fluid can predict fetal lung maturity. Measuring optical density of amniotic fluid correlates with lecithin/sphingomyelin (L/S) ratios, aiding in clinical decisions.

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    Area of Science:

    • Obstetrics and Gynecology
    • Neonatal Medicine
    • Clinical Chemistry

    Background:

    • Assessing fetal lung maturity is crucial for managing high-risk pregnancies.
    • Lecithin/sphingomyelin (L/S) ratio is a standard but time-consuming method.
    • A rapid, reliable alternative is needed for timely clinical intervention.

    Purpose of the Study:

    • To develop and validate a simple, rapid test for predicting fetal lung maturity.
    • To establish correlation between a new optical density test and L/S ratios.

    Main Methods:

    • Centrifugation of fresh, unfrozen amniotic fluid at 200g for 10 minutes.
    • Measurement of optical density at 650 nm.
    • Correlation analysis with established L/S ratios.

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    Main Results:

    • Optical density readings ≥ 0.15 showed 100% correlation with L/S ratios ≥ 2.0.
    • Optical density readings < 0.15 showed 94% correlation with L/S ratios < 2.0.
    • The developed test provides a rapid assessment of fetal lung maturity.

    Conclusions:

    • A simple optical density test offers a fast and accurate method for predicting fetal lung maturity.
    • This test correlates well with L/S ratios, providing valuable clinical information.
    • The test can aid in optimizing the timing of delivery for high-risk pregnancies.