Gingival granular cell myoblastoma in newborns. Report of two cases

Granular cell myoblastoma is a relatively rare and, exceptionally, malignant tumor. Here we report on two cases found in the gingiva in newborns. None of the previously described congenital lesions has been malignant. The treatment is always wide surgical excision and observation for possible recurrence. Neuron Specific Enolase (NSE) and S-100 protein immunoperoxidase studies revealed that cells of the granular cell myoblastoma react positively for both antigens, thus confirming the neurogenic origin of this tumor.